2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Cannabinoid Receptor

Cannabinoid Receptor

Cannabinoid Receptor

Cannabinoid Receptor

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Cannabinoid receptors are currently classified into three groups: central (CB1), peripheral (CB2) and GPR55, all of which are G-protein-coupled. CB1 receptors are primarily located at central and peripheral nerve terminals. CB2 receptors are predominantly expressed in non-neuronal tissues, particularly immune cells, where they modulate cytokine release and cell migration. Recent reports have suggested that CB2 receptors may also be expressed in the CNS. GPR55 receptors are non-CB1/CB2 receptors that exhibit affinity for endogenous, plant and synthetic cannabinoids. Endogenous ligands for cannabinoid receptors have been discovered, including anandamide and 2-arachidonylglycerol.

Cannabinoid Receptor Isoform Specific Products:

Cannabinoid Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-117754
    PSB-SB1202
    		Agonist
    PSB-SB1202 (Compound 21a) is a phenyl coumarin compound. PSB-SB1202 is a CB1/CB2 agonist with EC50 values of 56 and 14 nM, and Ki values of 32 and 49 nM, respectively.
    PSB-SB1202
  • HY-168368
    exo-Tetrahydrocannabivarin
    		Ligand
    exo-Tetrahydrocannabivarin (Compound 12) is a Δ9,11-THC analogue. exo-Tetrahydrocannabivarin weakly binds to cannabinoid receptors (CB) (IC50: 1.4 μM). exo-Tetrahydrocannabivarin is active on both motor and analgesic aspects in mice.
    exo-Tetrahydrocannabivarin
  • HY-170734
    Cannabidiol-C8
    Cannabidiol-C8 is structurally similar to known phytocannabinoids.
    Cannabidiol-C8
  • HY-170696
    Δ8-THCPA-A
    Δ8-THCPA-A (Δ8-Tetrahydrocannabiphorolic acid) is structurally similar to known phytocannabinoids.
    Δ8-THCPA-A
  • HY-170703
    Carmagerol
    Carmagerol is a phytocannabinoid metabolite.
    Carmagerol
  • HY-168789
    8(R)-Hydroxy-9(R)-hexahydrocannabinol
    8(R)-Hydroxy-9(R)-hexahydrocannabinol, a phytocannabinoid compound, is a metabolite of 9(R)-Hexahydrocannabinol.
    8(R)-Hydroxy-9(R)-hexahydrocannabinol
  • HY-170039
    (±)-8'-Hydroxy cannabichromene
    8'-Hydroxy cannabichromene is a phytocannabinoid metabolite.
    (±)-8'-Hydroxy cannabichromene
  • HY-14137R
    Rimonabant (Hydrochloride) (Standard)
    		Antagonist
    Rimonabant (Hydrochloride) (Standard) is the analytical standard of Rimonabant (Hydrochloride). This product is intended for research and analytical applications. Rimonabant Hydrochloride (SR 141716A Hydrochloride) is a highly potent and selective central cannabinoid receptor (CB1) antagonist with an Ki of 1.8 nM. Rimonabant Hydrochloride (SR 141716A Hydrochloride) also inhibits Mycobacterial membrane protein Large 3 (MMPL3).
    Rimonabant (Hydrochloride) (Standard)
  • HY-172043
    5-Fluoro PB-22 N-(2-fluoropentyl) isomer
    5-Fluoro PB-22 N-(2-fluoropentyl) isomer is a derivative of cannabinoid.
    5-Fluoro PB-22 N-(2-fluoropentyl) isomer
  • HY-W775348
    Tetrahydrocannabiphorol
    Tetrahydrocannabiphorol (THCP) is a phytocannabinoid.
    Tetrahydrocannabiphorol
  • HY-168817
    Δ9-Tetrahydrocannabiorcol
    Δ9-Tetrahydrocannabiorcol is structurally similar to known phytocannabinoids.
    Δ9-Tetrahydrocannabiorcol
  • HY-170733
    Cannabidiol monomethyl ether
    Cannabidiol monomethyl ether is a phytocannabinoid.
    Cannabidiol monomethyl ether
  • HY-168813
    Δ9-THCH
    Δ9-THCH is structurally similar to known phytocannabinoids.
    Δ9-THCH
  • HY-170726
    (±)-CBCP
    (±)-CBCP ((±)-Cannabichromephorol) is structurally similar to known phytocannabinoids.
    (±)-CBCP
  • HY-W775308
    Cannabicyclolic acid
    Cannabicyclolic acid is a certified reference material categorized as a photodegradation product of the phytocannabinoid Cannabichromenic acid.
    Cannabicyclolic acid
  • HY-170700
    CHM-FUBIATA
    CHM-FUBIATA is structurally similar to known synthetic cannabinoids.
    CHM-FUBIATA
  • HY-172056
    PB-22 N-Pentanoic acid-3-carboxyindole metabolite
    PB-22 N-Pentanoic acid-3-carboxyindole metabolite is a metabolite of PB-22. PB-22 is a cannabinoid.
    PB-22 N-Pentanoic acid-3-carboxyindole metabolite
  • HY-170044
    iso-Hexahydrocannabinol
    iso-Hexahydrocannabinol is structurally similar to known phytocannabinoids.
    iso-Hexahydrocannabinol
  • HY-14753
    Rosonabant
    		Antagonist
    Rosonabant is a selective antagonist for cannabinoid receptor (CB1 receptor), which reduces body weight and improves improves the risk of obesity-related cardiovascular metabolic diseases. Rosonabant exhibits adverse side effect, such as nausea and mental disorder.
    Rosonabant
  • HY-114826S
    Prostaglandin E2-1-glyceryl ester-d5
    		Activator
    Prostaglandin E2-1-glyceryl ester-d5 (PGE2-1-glyceyl ester-d5) is deuterium labeled Prostaglandin E2-1-glyceryl ester. Prostaglandin E2-1-glyceryl ester, a Prostaglandin Glycerol Ester, is an endocannabinoid ligand for the CB1 receptor. Prostaglandin E2-1-glyceryl ester induces rapid, transient elevation of intracellular free Ca2+.
    Prostaglandin E2-1-glyceryl ester-d<sub>5</sub>
Cat. No. Product Name / Synonyms Application Reactivity
Cannabinoid Receptor Isoform Comparison

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